[Luận văn tiếng Anh] Link prediction in heterogeneous information networks and its applications in predicting associations between non-coding RNAs and diseases

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CONTENTS
AUTHORSHIP'S DECLARATION  ......................................................................  i
ACKNOWLEDGEMENT.....................................................................................  ii
CONTENTS  ..........................................................................................................iii
ABBREVIATIONS...............................................................................................  vi
LIST OF TABLES  ...............................................................................................  vii
LIST OF FIGURES  ............................................................................................  viii
INTRODUCTION  .................................................................................................  1
CHAPTER 1. BACKGROUND  ..........................................................................  10
1.1.  Basic concepts.................................................................................................  10
1.1.1.  Heterogeneous information networks  .................................................  11
1.1.2.  Biological systems  .............................................................................  13
1.1.3.  Non-coding RNAs (ncRNAs)  ............................................................  14
1.2.  Link prediction in heterogeneous information networks  ..................................  15
1.2.1.  Link prediction problem.....................................................................  15
1.2.2.  Link prediction methods  ....................................................................  16
1.2.3.  Link prediction applications in biological systems  .............................  19
1.3.  Computational methods for predicting associations between non-coding RNAs 
and diseases  ...........................................................................................................  22
1.3.1.  Predicting non coding RNA-disease association prediction as a link 
prediction problem  ..........................................................................................  22
1.3.2.  Materials used for ncRNA-disease association prediction  ..................  22
1.3.3.  Similarity calculation and network construction  .................................  26
1.3.4.  Literature review of computational methods to predict ncRNA-disease 
associations  .....................................................................................................  27
1.4.  Thesis’s research directions  .............................................................................  36
1.5.  Some evaluation methods and metrics to evaluate prediction performance  ......  37
1.5.1.  Cross-validation  .................................................................................  37
1.5.2.  Area under Roc Curve (AUC)  ............................................................  38
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